NVS » Topics » NOVARTIS VACCINES INSTITUTE FOR GLOBAL HEALTH

This excerpt taken from the NVS 6-K filed Feb 9, 2010.

NOVARTIS VACCINES INSTITUTE FOR GLOBAL HEALTH

Targets 2009

Results 2009

Targets 2010

First vaccine (a conjugate for typhoid fever) enters pilot-scale GMP (good manufacturing practices) production. Prepare start of clinical trials in 2010. Develop process for pilot-scale GMP production in 2010 for vaccines for paratyphoid in Asia and non-typhoid Salmonella in Africa.

Plans in place to begin clinical trials of typhoid vaccine. Manufacturing process established and clinical grade material available. Manufacturing methods also demonstrated on laboratory scale for additional vaccines — against paratyphoid fever, nontyphoid Salmonella and Shigella.

Start Phase I and Phase II of typhoid vaccine trials in Europe and India. Launch pilot scale manufacture of the paratyphoid vaccine. Develop pilot scale process for nontyphoid Salmonella and Shigella vaccines.

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This excerpt taken from the NVS 6-K filed Feb 9, 2009.

NOVARTIS VACCINES INSTITUTE FOR GLOBAL HEALTH

Vaccines against infectious diseases save the lives of an estimated 2 million children every year, but an additional 2.5 million still die from diseases preventable by vaccines. According to the World Health Organization, vaccination is one of the most cost-effective health investments, and there is an urgent need for vaccines against many “neglected diseases” that take a heavy toll in the developing world.

In 2007, Novartis opened the Novartis Vaccines Institute for Global Health (NVGH), a new research institute with a nonprofit mission of focusing exclusively on vaccines against diseases of the developing world. The institute, based in Siena, Italy, is the first of its kind to be established by a major vaccine manufacturer.

It is the goal of NVGH to discover vaccines specifically tailored for the needs of developing countries and to license development to third parties. All vaccines discovered by the institute that receive regulator approval will be introduced first in developing countries, and provided at an affordable and accessible price to populations of the developing world.

The mission of NVGH mirrors the Singapore-based Novartis Institute for Tropical Diseases (NITD), established in 2003. Both institutes focus on research and early stages of development, to the point of proof-of-concept in humans. And medicines discovered at NITD will be made available to countries in which the diseases are endemic at no profit to Novartis.

Research activities at NVGH center around conjugate vaccines for enteric, or intestinal, diseases. Initial priorities for NVGH are major causes of infection and disease in children, including Salmonella enterica serovar Typhi, Salmonella paratyphi A and nontyphoidal salmonellae (NTS). In Africa, resistant NTS is a major killer of children younger than 5 years old, second only to pneumococcal disease.

NVGH will have dedicated management, scientists and resources and access to expertise and innovative technology platforms at the Novartis Vaccines and Diagnostics Division’s global research center, also in Siena.

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EXCERPTS ON THIS PAGE:

6-K
Feb 9, 2010
6-K
Feb 9, 2009